Oxacillin sodium hydrate
- CAS number
- 7240-38-2
- Application
- Beta-lactam antibiotic, which inhibits bacterial cell wall synthesis by binding to the penicillin-binding proteins in the bacterial cell wall. Oxacillin has been used as a model for experimental studies of infectious diseases and as an analytical method for antibiotic sensitivity testing. The drug has been shown to have vancomycin-interactive effects and may be used in combination therapy with other antibiotics. Oxacillin sodium has also been shown to inhibit chemiluminescence activity in bacteria. This inhibition was due to its ability to bind to and inhibit the function of DNA polymerase, which is required for DNA replication. Oxacillin sodium can be used as an antibacterial agent through its ability to inhibit bacterial growth by binding to and inhibiting DNA polymerase activity.
- Molecular weight
- 441.43 g/mol
- Molecular formula
- C19H18N3O5S.Na.H2O
- Routes
- Intravenous
SOCOSUR PDE monographs are a quick and efficient way to obtain:
- Risks identification
- Identification of potential critical effects
- Rationale for NOAEL values selection
- Complete description of adjustment factors F1 to F5 as well as PK correction
- Complete review of all relevant pharmaceutical and medical databases, public or private, European or not in accordance with EMA guideline EMA/CHMP/CVMP/SWP/169430/2012, signed by an European toxicological expert with full CV
Benefits of such PDE monograph
A 16 to 25 pages report optimized in case of Regulatory Body inspection with all calculation details and all bibliographic references linked to these calculations.
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